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Western Blot Data with Conventional HRP

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WEBwww.ebioscience.com ORDER888.999.1371 TECH888.810.6168 INQUIRIEScontact@ebioscience.com 19

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contents

DePARtMents

13 editorial the Importance of a Plan B Even when the source of your salary is the government, it’s not a guarantee.

BY RichARD GALLAGheR

19 notebooks Agenda; speciation’s roots?; new look at old wounds; Brain quakes; A life behind life science; the media monitor

28 opinion When collaborations compete What to do when you know two scientists are competing with each other, and they don’t.

BY STeWART LYMAn

31 column Hypothesis-Free? no such thing Even so-called “discovery-driven research” needs a hypothesis to make any sense.

BY STeVen WiLeY

56 Profile switched on science James Collins has shifted gears from medical engineering to gene switches, and won a MacArthur grant along the way.

BY KARen hOPKin

61 the Literature Hot Papers: Two ribosome structures ignite debate and discovery; new compound that fights drug-resistant bacteria; scientists pin down the minimum number of essential bacterial genes; a potential new vaccine vector not suppressed by preexisting immunity. Citation Classic: A chemist recalls how he used a nascent technology to capture the subatomic properties of a key reaction. Scientist to Watch: Howard Hang

67 Lab tools sweet Attachments Isolating and detecting glycosylated proteins.

BY JeFFReY M. PeRKeL

75 BioBusiness Dandruff Genomics At Proctor & Gamble, Thomas Dawson has led the charge to put more biology in every bottle of shampoo.

BY BRenDAn BORReLL

87 careers Getting on Board How serving on a scientific advisory board can serve you well.

BY BOB GRAnT

96 Foundations Wistar Melanoma Lines, circa 1977

In eVeRY IssUe

11 contributors

14 Mail Translational disconnect; Bias out of the bottle; The impact of impact factor; It isn’t just about innovation; Wonderful WNT; Abnormal benefits?; Fooled by fraud?

72 the Guide

90 Recruitment

May 2008 The ScienTiST